San Francisco 49ers Game Logs
| event date | Opponent | Type | Result | score | ATS | Line | OU | Total | preview available | recap available |
|---|---|---|---|---|---|---|---|---|---|---|
| Aug 12, 2022 | vs Green Bay | PRE | W | 28-21 | W | -3 | O | 35.5 | No | Recap |
| Aug 20, 2022 | @ Minnesota | PRE | W | 17-7 | W | 3.5 | U | 38 | No | Recap |
| Aug 25, 2022 | @ Houston | PRE | L | 17-0 | L | -2.5 | U | 40.5 | No | Recap |
| Sep 11, 2022 | @ Chicago | REG | L | 19-10 | L | -6.5 | U | 38 | Preview | Recap |
| Sep 18, 2022 | vs Seattle | REG | W | 27-7 | W | -8.5 | U | 39.5 | Preview | Recap |
| Sep 25, 2022 | @ Denver | REG | L | 11-10 | L | -1.5 | U | 44.5 | Preview | Recap |
| Oct 3, 2022 | vs LA Rams | REG | W | 24-9 | W | -2 | U | 42 | Preview | Recap |
| Oct 9, 2022 | @ Carolina | REG | W | 37-15 | W | -6 | O | 39.5 | Preview | Recap |
| Oct 16, 2022 | @ Atlanta | REG | L | 28-14 | L | -3.5 | U | 45.5 | Preview | Recap |
| Oct 23, 2022 | vs Kansas City | REG | L | 44-23 | L | 1 | O | 49 | Preview | Recap |
| Oct 30, 2022 | @ LA Rams | REG | W | 31-14 | W | 1 | O | 42 | Preview | Recap |
| Nov 13, 2022 | vs LA Chargers | REG | W | 22-16 | L | -8 | U | 45.5 | Preview | Recap |
| Nov 21, 2022 | @ Arizona | REG | W | 38-10 | W | -9.5 | O | 43 | Preview | Recap |
| Nov 27, 2022 | vs New Orleans | REG | W | 13-0 | W | -8.5 | U | 43.5 | Preview | Recap |
| Dec 4, 2022 | vs Miami | REG | W | 33-17 | W | -5 | O | 46 | Preview | Recap |
| Dec 11, 2022 | vs Tampa Bay | REG | W | 35-7 | W | -3.5 | O | 38.5 | Preview | Recap |
| Dec 15, 2022 | @ Seattle | REG | W | 21-13 | W | -3 | U | 42.5 | Preview | Recap |
| Dec 24, 2022 | vs Washington | REG | W | 37-20 | W | -6.5 | O | 37 | Preview | Recap |
| Jan 1, 2023 | @ Las Vegas | REG | W | 37-34 | L | -10 | O | 41 | Preview | Recap |
| Jan 8, 2023 | vs Arizona | REG | W | 38-13 | W | -14.5 | O | 40 | Preview | Recap |
| Jan 14, 2023 | vs Seattle | PST | W | 41-23 | W | -9.5 | O | 42 | Preview | Recap |
| Jan 22, 2023 | vs Dallas | PST | W | 19-12 | W | -3.5 | U | 46.5 | Preview | Recap |
| Jan 29, 2023 | @ Philadelphia | PST | L | 31-7 | L | 3 | U | 44.5 | Preview | Recap |