Pittsburgh Panthers Game Logs
| event date | Opponent | Type | Result | score | ATS | Line | OU | Total | preview available | recap available |
|---|---|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | vs Massachusetts | REG | W | 51-7 | W | -37.5 | O | 56 | Preview | Recap |
| Sep 11, 2021 | @ Tennessee | REG | W | 41-34 | W | -4 | O | 56 | Preview | Recap |
| Sep 18, 2021 | vs Western Michigan | REG | L | 44-41 | L | -14 | O | 58.5 | Preview | Recap |
| Sep 25, 2021 | vs New Hampshire | REG | W | 77-7 | W | -29 | O | 53 | Preview | No |
| Oct 2, 2021 | @ Georgia Tech | REG | W | 52-21 | W | -3 | O | 57.5 | Preview | Recap |
| Oct 16, 2021 | @ Virginia Tech | REG | W | 28-7 | W | -6 | U | 56 | Preview | Recap |
| Oct 23, 2021 | vs Clemson | REG | W | 27-17 | W | -3.5 | U | 47 | Preview | Recap |
| Oct 30, 2021 | vs Miami-FL | REG | L | 38-34 | L | -9.5 | O | 61 | Preview | Recap |
| Nov 6, 2021 | @ Duke | REG | W | 54-29 | W | -21 | O | 64.5 | Preview | Recap |
| Nov 11, 2021 | vs North Carolina | REG | W | 30-23 | W | -6.5 | U | 72 | Preview | Recap |
| Nov 20, 2021 | vs Virginia | REG | W | 48-38 | L | -13 | O | 67.5 | Preview | Recap |
| Nov 27, 2021 | @ Syracuse | REG | W | 31-14 | W | -11.5 | U | 58.5 | No | Recap |
| Dec 4, 2021 | @ Wake Forest | REG | W | 45-21 | W | -3.5 | U | 73.5 | No | Recap |
| Dec 30, 2021 | @ Michigan State | PST | L | 31-21 | L | 3.5 | U | 55 | Preview | Recap |